This paper, based on the regional sustainable development mechanism, discusses the resource-environment industrial transformation in Beijing-Tianjin-Hebei, analyzes the heterogeneity, openness and difference in regional industrial structures, which shall be integrated so as to achieve the complementarity during regional industrial development. Under the resources and environment and ecological capacity, this paper discusses how to set up an integration mechanism of regional development and urban space, and presents some suggestions on industrial transformation and structural adjustment.